- Twin brother of actor Jeremy London.
- He played Joey Lauren Adams's boyfriend in La vita è un sogno (1993) while his identical twin brother Jeremy London played her ex-boyfriend in Generazione X (1995). Coincidentally, Ben Affleck also appeared in both films.
- His younger sister, Dedra London, died in a car accident in 1992, when she was 16.
- He and his identical twin brother Jeremy London made guest appearances on Oltre i limiti (1995).
- Shannen Doherty was godmother to his daughter, Cooper.
- He is part Cherokee Indian.
- He grew up in a family of five children; he, twin-brother Jeremy London, younger sister Dedra London and two step-siblings.
- Daughter Cooper London was born to him and wife Charlie Spradling on his 24th birthday [7 November 1996].
- Chosen by People (USA) magazine as one of the 50 most beautiful people in the world. (1996)
- His mother is Debbie London. She divorced his father when he was very young, and Jason and his siblings lived with their mother after the divorce.
- Ex-brother-in-law of Melissa Cunningham.
- Brother-in-law of Juliet Reeves London.
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