- She is a friend of Fran Drescher and it was Drescher's interaction with Twiggy's children that was used as the basis for Drescher's hit show La tata (1993).
- Appeared with David Bowie on the cover of his "Pin Ups" album, and is mentioned in his song "Drive in Saturday" from his Aladdin Sane album.
- Her first marriage, to American actor, Michael Witney, ended with his sudden death from a heart attack.
- She credits Jean Shrimpton as her greatest idol and considers her the world's first supermodel.
- Was regarded as "the face of 1966" in swinging London and gained her nickname from her stick-thin pubescent figure.
- Gave birth to her only child at age 29, a daughter Carly Witney on December 1, 1978. Child's father was her first husband, Michael Witney.
- Met her second husband Leigh Lawson on the set of Madame Sousatzka (1988) in 1988.
- Attended Cynthia Lennon's wedding to Roberto Bassanini.
- She was the youngest person to ever be surprised by the Big Red Book on This Is Your Life (1955) , aged 19 at the time.
- Has one granddaughter, Joni (b. May 2016), via daughter Carly and her husband, Ben Wiggins.
- She was awarded the Dame Commander of the Order of the British Empire in the 2019 Queen's New Years Honours List for her services to Fashion, Arts and Charity in London, England.
- Is an accomplished singer and theater star.
- Is an avid supporter of animal rights organizations and breast cancer research groups.
- Was nominated for Broadway's 1983 Tony Award as Best Actress (Musical) for "My One and Only."
- Became pregnant by her first husband Michael Witney but suffered a miscarriage in January 1978 at two months pregnant.
- Was named "The Face of 1966" by the Daily Express.
- Started a clothing line through Great Universal called the Twiggy Collection for spring/summer 2006.
- Youngest daughter of Norman Hornby (a carpenter on Space Patrol (1963)) and his wife Nell Hornby (née Nellie Lydia Reeman).
- Made her return to modeling by fronting a major new TV, press and billboard campaign for Marks & Spencer, the chain department store of the UK. Her appearance alongside Erin O'Connor, Laura Bailey and other younger models is intended to portray the wide variety of choices of the M&S clothing range, as well as the fact that older women are equally entitled to look good.
- Model/actress
- Her manager was Justin de Villeneuve.who changed her name and became her manager/boyfriend, launched her to fame and were together for 9 years.
- Dated Warren Beatty.
- Has a sister Shirley who is 15 years older.
- Was ranked #9 in Channel 5's "World's greatest supermodel."
- Is one of 23 actresses who did not receive an Oscar nomination for their Best Actress in a Comedy/Musical Golden Globe-winning performance; hers being for Il boy friend (1971). The others, in chronological order, are: June Allyson for L'ingenua maliziosa (1951), Ethel Merman for Chiamatemi madame (1953), Jean Simmons for Bulli e pupe (1955), Taina Elg and Kay Kendall for Les Girls (1957), Marilyn Monroe for A qualcuno piace caldo (1959), Rosalind Russell for Il molto onorevole ministro (1961) and La donna che inventò lo strip-tease (1962), Patty Duke for Me, Natalie (1969), Raquel Welch for I tre moschettieri (1973), Barbra Streisand for È nata una stella (1976), Bernadette Peters for Spiccioli dal cielo (1981), Kathleen Turner for All'inseguimento della pietra verde (1984) and L'onore dei Prizzi (1985), Miranda Richardson for Un incantevole aprile (1991), Jamie Lee Curtis for True Lies (1994), Nicole Kidman for Da morire (1995), Madonna for Evita (1996), Renée Zellweger for Betty Love (2000), Sally Hawkins for La felicità porta fortuna - Happy Go Lucky (2008), Amy Adams for Big Eyes (2014), Awkwafina for The Farewell - Una bugia buona (2019), Rosamund Pike for I Care a Lot (2020) and Rachel Zegler for West Side Story (2021).
- Delivered her daughter Carly naturally with an epidural and breastfed her for six weeks.
- Tried out for Romeo e Giulietta (1968) but failed to pass the audition.
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