- Younger brother of actors Joey Lawrence and Matthew Lawrence.
- His father is of Italian descent and his mother has English and Northern Irish ancestry.
- He directed two movies that he wrote himself called "Money Plane" and "Mistletoe Mixup". Both movies featured his brothers Matthew and Joey.
- When he was born Brandon Tartikoff (the president of NBC, who knew the Lawrence family thru Joey and Matthew on La piccola grande Nell (1981) and other work for NBC) sent flowers to the hospital, and, as a joke, an acting contract for newborn Andy.
- Plays "Jason" on United States of Tara (2009). (aprile 2009)
- Uncle to older brother Joey's three daughters: Charleston "Charli" Lawrence, Liberty Grace Lawrence and Dylan Rose Lawrence.
- He is filming a movie in Texas (settembre 2004)
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