A causa di una cospirazione politica, un innocente viene mandato nel braccio della morte e la sua unica speranza è suo fratello, che farà di tutto per farsi spedire deliberatamente nella stessa prigione per poter evadersi insieme.
Everything in Scott McCall's life is starting to fall into place. He gets a spot on the First Line of his Lacrosse team and a date with the woman of his dreams. But when he gets bitten by a wolf, the people around him could be in danger.
Seven years have passed, with everyone having moved on with their lives. Michael is discovered to still be alive after his apparent death and has ended up in a Yemeni prison. Lincoln gets a visit from a familiar face and learns the news about Michael and his whereabouts.
Dangerous threats keep Michael and Lincoln fighting to protect Sara and Mike. Meanwhile, Poseidon continues to try and outsmart Michael and the rest of the gang, which leads them to the ultimate showdown, and not everyone makes it out alive.
As Lincoln and C-Note search for the "Sheik of Light," Michael and his cellmate, Whip, attempt an escape from Ogygia. Meanwhile, Sara's investigation into Michael's reappearance leads her to the state department and an uneasy reunion with Paul Kellerman.
When T-Bag ambushes Sara, he warns her that two of Poseidon's henchmen, Van Gogh and A&W, may be following her. Meanwhile, Lincoln attempts to retrieve his confiscated passport to escape Yemen, and Michael plans his next move.
Michael, Lincoln and the Ogygia gang race through the desert pursued by Cyclops; A&W and Van Gogh question their roles when their trailing the escapees leads them to Graceland.
Sara fears for her family's safety when she discovers the reason why Michael faked his death; Sucre helps Michael and Lincoln find a way home; Poseidon's true identity is revealed.
Michael and Lincoln enlist the help of Sheba and C-Note to catch Poseidon when Sara and her son are threatened; Whip takes a separate mission; T-Bag reveals a secret.
