Le cellule staminali, la terapia genica, i trapianti e la clonazione hanno cambiato la definizione di umanità nel mondo moderno, ma il lato più oscuro contiene mostri che pochi coraggiosi affronteranno, perché il futuro è nelle loro mani.
While tracking a young boy with dangerous powers, Dr. Helen Magnus encounters Will Zimmerman, a psychiatric resident who may have what it takes to become her new protege.
When an old friend of Will's goes missing his wife contacts him for help. With the help of Helen and Ashley, Will finds that his friend has been taken and forced to fight underground. But as they continue to search, things start to become quite familiar to Helen.
Desperate to get her first exclusive story, a reporter and her cameraman sneak inside an evacuated building. Inside they find Dr. Magnus and her team, and a creature greater than any of them were prepared for.
When abnormals begin to suddenly and inexplicably come out into the open and start killing humans, Helen recognises a viral attack and works with some old friends to create a cure.
With Ashley and Henry in the hands of the Cabal the rest of the team venture to a remote vampire enclave to recover the last known sample of vampire blood; the power they need to defeat the Cabal.
When Dr. Magnus, Will and Ashley rescue three entombed women Will struggles to accept that the women are suffering from anything more than a group delusion, Dr. Magnus suspects that the women are much more than they appear.
After thieves make a dramatic escape that baffles police Dr. Magnus suspects an abnormal's involvement. The robbery reminds Will of an old FBI case he could not solve; but this time he will.
After capturing a particularly elusive abnormal the plane carrying Dr. Magnus and Will crashes while transporting the creature. Dr. Magnus and Will soon discover why this abnormal has never been captured before.
Dr. Magnus, Ashley and Will retrieve two species of abnormal that have the ability to camouflage so well that they are near invisible. One appears to be a vicious predator, the other a cute, furry animal but nothing is as it appears.
While speaking at a conference Magnus is met by an old friend, come to warn her that the Cabal is on their way. Except his motives aren't what they seem. Back at the mansion, Big Guy nurses a sick Henry and Will hunts a dangerous abnormal.
Henry comes to terms with his abnormal side, Ashley works through her feelings about her parents, and Will helps a young autistic man whose father possibly shot himself.
In the wake of an unexpected betrayal, the Sanctuary must pull together to figure out the Cabal's master scheme in time to save those closest to them and the whole world.
The Sanctuary team hunts down a man who seems to have superpowers, calling himself "The Adjuster." But they discover that his suit is the source of his power, and it is slowly killing him. But he can't get it off.
The Cabal's new "Super-Abnormals" begin destroying Sanctuaries around the world. It won't be long before they launch their attack on the Old City Sanctuary, and Magnus must choose between saving Ashley and saving the Sanctuary Network.
Kate accidentally sets loose a baby Abnormal that she and Henry discover grows very quickly. Meanwhile, Magnus searches desperately for a way to bring back Ashley.
When Dr. Magnus awakes to darkness, she must face a destroyed Sanctuary, city, and even world. But beneath the apocalypse, something deeper awaits her discovery if she can find it in time.
When a scientist, and close friend of Henry's is attacked by the abnormal she is working with, Magnus attempts the impossible to save her life. Meanwhile Henry reconstructs the scene and makes some confusing discoveries.
When Bigfoot is discovered dead, all of the evidence points to Magnus. Will, Henry, and Kate must find a way to clear her name and find out who actually committed the crime before she is replaced.
While transporting a usually docile abnormal, Magnus's helicopter crashes, leaving her and Will stranded in the shaft of an abandoned oil rig. They soon find they are not alone in the water.
While an old friend of Magnus', a pouched abnormal named Jimmy, is handing over a fire elemental to the Sanctuary team, they are attacked by a gang of criminal abnormals from Chicago. The situation presents a lot of mysteries to be solved and quickly.
Big Bertha is not happy, but Dr. Magnus has a suggestion for how Will might once again be able to contact her, through her Kali avatar. Third and final installment of the Kali trilogy.
