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Wayne Szalinski è un genio maldestro che inventa sempre nuovi gadget ed esperimenti, ma di solito qualcosa va storto e mette Wayne e la sua famiglia nei guai, nel pericolo e nell'avventura fantastica.

Dr. Thomas Barlow, one of the few doctors in the frozen Arctic region, fights to bring help to an isolated, virtually inaccessible Eskimo village in the Arctic that had been devastated by plague. Based on a true story.

Wayne makes gadgets for spies in Canada. Now they are on a mission to stop a missile from blowing up the moon as the situation becomes increasingly complicated. Diane acts as a spy to discover more information and ends up with a don who takes her as a call girl. She bravely shares bed with him while her daughter is tortured by thugs.

Nick wants to appear on a show called Smart Mouth because he believes he knows everything. Everyone tells him that he is too young so Nick makes a chemical which accelerates his aging process, turning him into a grown man overnight. But his parents eventually create an antidote so now they must convince Nick to go back to normal or he will be a grown up forever.

Wayne's brother Randy Rude the Science Dude comes to town with his show. He invites Wayne to help him get the ratings up. Wayne agrees to help but unbeknownst to him, he started taking over. When he realises this, he plans a way to pay back for all the times that he has taken over.

Wayne turns Amy's bicycle into a super speed mountain bike. Amy goes on a bike ride through the woods, crashes, twists her ankle and finds refuge in a cave. Amy meets Bigfoot and she names him George after Curious George. He saves her and takes Amy to her house. Now the family must get him back along with his wife, a Yeti.

While Wayne works on controlling the cloning of himself, one of his new selves takes his place at work, where Bianca becomes suspicious of his geniality. Wayne is down because his clone is doing better than the real him. She gives his clone a friendship bracelet that is a tracking device, she befriends the clone and then uses him to kidnap Wayne.

Wayne's chemical to increase intelligence has different effects on the family, including mind reading and levitation, while their dog, Quark, is able to hypnotise people.

Wayne accidentally shrinks himself and his brother, Randy, who find themselves in little trouble when they are mistaken for McDonald's Happy Meal Toys and brought home to a young boy who happens to be a fan of Randy's television series "Randy Rude: The Science Dude".

Wayne's comment at a seminar offends some witches. The witches cast spells on the family. Now they must stop the witches and get Nick back.

The prospect of dissecting a frog is giving Nick nightmares so Wayne invents a dream machine that would go into Nick's dream. He kills the frog but is threatened never to come back into the dream world again. Amy, against her dad's wishes, goes in so she can annoy Nick, so now the family can't sleep or else they could die.

Amy's science teacher quits unexpectedly so her dad volunteers to teach. He makes a formula to make him charming so that the students will like him. Amy catches him and tries to alter the formula, however something goes wrong and the formula makes Wayne act like a bad person. Now it is up to the rest of the family to find a way to get Wayne back. Meanwhile, Diane and Nick try to give Quark a bath.

Wayne invents something that could make your vision perfect so Nick tries it out and can see practically anything, even dead people. He befriends a "friendly" ghost who gets into Wayne's body and Nick realises that the ghost isn't all that good. So he along with Wayne attempt to get control of his body so they can get the ghost out.

Wayne works on a superhero suit to combat a crime wave by off-road bikers. Will this invention work or will it backfire like usual?

Wayne invents an invention called the 3iDer which turns people into different people. The invention and Wayne got nominated for the inventors recognition achievement award. An evil clown tries to steal the invention and frame Wayne so it is up to Team Szalinski to stop this clown and clear Wayne's name.

Jennings bets his company on a golf game even though he can't play very well. He asks Wayne to build golf clubs to help them win but Jennings gets hurt so Wayne has to play. Meanwhile Diane, and the kids are feeling crowded with Wayne's invention so they decide to sell the stuff they don't use but after a while people don't like them so now they have to get them all back.

Nick is upset because he is having trouble playing baseball so he asks his dad to make some inventions to help him play baseball better. Elsewhere, Diane is worried about her recital and Amy uses a cream that camouflage pimples but she uses too much and it hides her nose.

Wayne feels overwhelmed with the demands of work and his family so he invents something that will make him go from place to place in seconds. He sets the level on high and somehow travels at the speed of light. Jennings finds a copy of the invention and is travelling fast too and playing tricks on people. The two of them get stuck at hyperspeed and must use another Szalinski invention to slow their molecules.

After wrestlers Bret Hart and Owen Hart are injured at the Szalinskis' house, Wayne and the Chief agree to take their places in a match, aided by Wayne's remote-controlled bodysuit.

Since Diane is allergic to chocolate Wayne tries to remove the allergic compound from the chocolate, but accidentally creates a chocolate that makes people fall in love. Damon, Amy's best friend, has a crush on Amy and Nick tries to get Amy to eat the chocolate. When she finds out how the chocolates work, she tries to get her crush "the make out king" to eat it. Diane, Wayne, Tiara, and a mutated Dr. Jennings also eat the chocolates, so Nick has to find the antidote that will make everyone (relatively) normal again.

Amy writes a good story about her dad and his inventions. Two mobsters, one that looks like Wayne, finds Wayne and decides to switch, so they can get in the clear. They kidnap Wayne and the bad guy goes into the house. After a while Wayne gets taped and tied at a hotel and Amy figures out what's going on. Will the bad guys get caught and will Wayne get home safely?

To save his bankrupt company, Jennings sends Wayne to find a magical stone that can turn metal into gold. However, Jennings' greed alters the stone's power.

Wayne makes police equipment for the Chief. Jake is running to be chief for another two years is reluctant, and won't listen the rest of the family. The family are at a community service, serving meals where the people protest and the cook quits. Also, a jewel thief ties the family up. Wayne goes after Jack to warn him and save his family.

A criminal gang of traveling washed up circus performers robs the Szalinskis' home, steals the shrink ray and kidnaps Wayne Szalinski's little son to get him to show them how to use it.

Diane's sister, Elaine, is in town and as Wayne doesn't like her he invents something so he can't understand her. As usual Wayne's creation goes wrong and Elaine's personality gets into Wayne's brain. Now the family must work together to get everything back to normal without the help of Wayne.