We follow the journey of James Cole, a time traveller from a post-apocalyptic future, who heads to the present to stop a plague that will eventually decimate the human race.
Time Traveller James Cole's search for information about a mysterious organisation known as the Army of the 12 Monkeys leads him to a mental institution in 2015.
12 मंकीज की सेना से लड़ते-लड़ते कोल और डॉ. रैली को एक नाईट रूम मिलता है- एक ऑफ-साईट, ब्लैक ऑप्स लैब जहाँ वो वायरस रखा होता है जो एक दिन दुनिया को तबाह कर देगा.
After the events in the Night Room, Cole automatically returns to 2043 and finds that the timeline has been altered. He meets Jones, who has no idea who he is.
The Core that powers the time machine is fading. To get Cole back from the past, Jones must convince her former colleagues at the military operation "Spearhead" that her mission is worth saving.