Comedian Nick Helm (Andy) explained that the show was inspired by Wes Anderson's comedy film The Royal Tenenbaums (2001).
Uncle is filmed on-location in Croydon. Exterior scenes have been filmed at George Street, Thornton Heath and Surrey Street Market. Interior locations include the Hustler Club and a house in Purley.
The original pilot was broadcast on Channel 4, although the following two series were broadcast on rival channel BBC Three.
Following the decision to convert BBC Three into a digital-only channel, there was speculation that any potential third series of Uncle might be moved to BBC Two. However, in December 2015 the third series was announced by the BBC, with a strong suggestion that it would remain on BBC Three as an online broadcast, followed by repeats on BBC One.