- Hunter: If it's hostile, you kill it.
- Alex: You heard about survival of the fittest? Guess what? We lost!
- Artyom: I was filled with doubt. We had already scorched the Earth once. Now, the fire was in my hands, and I had to carry it through.
- Col. Miller: [Leading Artyom & the Rangers into D6] Forward, my soldiers! Great deeds await!
- Khan: [Commenting on the ghostly disembodied shadows that appear in some tunnels] It appears that the devastation we brought upon ourselves was complete; Heaven, Hell and Purgatory were atomized as well. So when a soul leaves the body it has nowhere to go, and must remain here, in the Metro. A harsh, but not undeserved atonement for our sins, wouldn't you agree?
- Red Army Conscript: [On the railcar approaching the front line between the communists and the Russian neo-nazis] So, are we getting paid, or what? Even Marx himself couldn't survive on ideals alone.
- Red Army Commissar: Of course you'll be paid! Ammo is money and we pay in advance: a full mag to each man! But as honorable soldiers, you are expected to spend that ammo on the enemy!
- Ulman: [Ulman has just killed two neo-nazis who were about to execute Artyom] You know, one thing I like about the bad guys is that there's always a lot of discussion before they get around to pulling the trigger.
- Ulman: [Referring to the furnace on a rail car] Great, time to warm up at the stove!
- Artyom: What the hell...?
- Yevgeniy/Eugine: [Yevgeniy needs to crank the hand-powered cart to escape the monsters in the tunnel] Artyom! Here, take my shotgun!