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Originally announced as Troma Entertainment's first PG-13 film since Sgt. Kabukiman N.Y.P.D. (1990) before given the R-rating

Remake of Troma Entertainment's R-rated 1984 low-budget action-comedy splatter film. The original film generated three sequels, and expanded into numerous variations including: a 1990 animated children's TV series spin-off called Toxic Crusaders, a musical stage production, and a Marvel comic book series.

Macon Blair confirmed that It's NOT Actually Peter Dinklage Under The Makeup As Toxie, "It's not Peter, It's a tiny British actress named Luisa Guerreiro. She's Portuguese. A complete badass. 110 degrees, 30 pounds of foam makeup. Motors all over her face to move the eyebrows and stuff like that. What she did was, and this is why I get so excited talking about it, Peter performed the whole movie on videotape as Toxie. Just himself. But making the choices, delivering the lines, physical choices, how fast he's running all of it. There's a video version of him just in a white room playing the whole movie. Luisa takes those tapes home, memorizes them, and studies them. She plays Teletubbies and Oompa Loompas. She's like a physical performer. So, she's studying his gait and his timing, his pauses, his line delivery, all of that. She replicates that on set, and then Peter, six months later, comes back and reinterprets the voice based on what she did. So, Toxie is actually Luisa playing Peter with Peter's voice playing Luisa."

Macon Blair and Peter Dinklage also starred in The Thicket (2024) together.

Taylour Paige and Jacob Tremblay shares the same birthday (October 5th) but were born in sixteen years apart from each other. Paige was born in 1990 and Tremblay was born in 2006.