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Based on the popular series of pregnancy guides by the same name. As of 2022, more than 22 million books have been sold.

Kristen Wiig was offered a role but declined, due to scheduling conflicts with Saturday Night Live (1975).

The Ethiopian boy Holly and Alex adopt, was played by twin Ethiopian boys, who were adopted in a similar ceremony only months before production began.

Elizabeth Banks, Jennifer Lopez and Brooklyn Decker are the only actresses cast as pregnant women who have given birth in real life; Lopez gave birth to twins, Decker gave birth to a son and Banks has two sons via a surrogate. Cameron Diaz gave birth via surrogate in December 2019 and Anna Kendrick has never had children.

Elizabeth Banks, Anna Kendrick, and Rebel Wilson also star together in Pitch Perfect (2012), Pitch Perfect 2 (2015), and Pitch Perfect 3 (2017).