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Executive Producers Jensen and Danneel Ackles (under their company Chaos Machine Productions) both starred in the TV series Supernatural. Jensen starred as series lead Dean Winchester in all 327 episodes across 15 seasons. Danneel was a guest star for 5 episodes as the angel Anael.

The Winchesters was picked up for a pilot order by The CW on 3 February 2022.

It was announced in May 2023 that the series had been cancelled by the CW network after one season due to low ratings. Warner Bros. Television, the studio which produced The Winchesters, vowed to shop the series around elsewhere.

Meg Donnelly and Drake Rodger are dating in real life

Jensen Ackles, the executive producer of the series has quite the commute, at least, in 2022. The series is filmed in Louisiana and he lives in Austin Texas. Moreover, he is a major character in Big Sky (2020), which is filmed in New Mexico. Louisiana and New Mexico are next-door neighbors of Texas.