Alphas was originally called "Section 8, Alphas" during development. Although initially developed in 2006, it wasn't until 2009 that it was picked up by a network.
With the appearance of Lindsay Wagner as Dr. Vanessa Calder in the episode "Never Let Me Go", ALPHAS is tied into the same "universe" as "Warehouse 13" and "Eureka".
Season 2 episode 12 the character Zoe (Skylar Wexler) asks Skylar Adams (Summer Glau) if a tracking device was a terminator. This is a homage to Summer Glau playing the part of Cameron Phillips and Allison Young in the Fox series Terminator: The Sarah Connor Chronicles (2008).
Co-stars Warren Christie & Laura Mennell would co-star once again together in another TV series called, "Motive (2014)
The shows cancellation was a major part of the plot of The Big Bang Theory episode "The Closure Alternative" (S6 E21).