Vince Vaughn's parents have bit roles in the movie. His mother plays a tourist and his father plays Jennifer Aniston's father.
Vince Vaughn gained 26 pounds for the role. Vaughn was reported to have gained weight as a result of his recent decision to quit smoking.
In a 2006 interview with Good Morning America, Jennifer Aniston joked about now being "very intimate" with her wardrobe and makeup people after they helped get her ready for her full nude scene. She also added being naked like that isn't something she normally does, even in her personal life. "I've never taken that long of a walk nude in my own home, so that was a first all the way around."
During an interview with the IndieLondon site, Jennifer Aniston was asked why she chose to take her clothes off for this film. "Well, I was getting paid money to do it and I didn't really have a choice because Vince wrote it!" She joked. Then she added "When I read it, truthfully, it was so long and extensive, I thought there's no way they could film it. It was literally, she walks down the hallway, through the living room, in front of the TV, goes into the kitchen and opens the fridge, takes out a coca cola, etc etc. I thought well this is going to be an NC-17, there's no way they can shoot that. But sure enough, they figured out a way to shoot it very tastefully. But it didn't feel gratuitous in any way."