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William Devane (Black Jack Bouvier) previously played John F. Kennedy in The Missiles of October (1974).

Josef Sommer (Joseph Kennedy Sr.) and Joss Ackland (Aristoteles Onassis) both co-starred together in The Mighty Ducks (1992). Although they never shared any scenes together.

President Kennedy was 43 years old when inaugurated in January of 1961.

While filming A Woman Named Jackie, Stephen Collins (John F. Kennedy) was 35, the exact same age as JFK when he became the 35th President of the United States in 1961.