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The show's premise of a recovering alcoholic hit too close to home, as Brett Butler was an alcoholic in real life. She drunkenly fought for creative control, resulting in five producers either quitting or being forced out in the five years the sitcom was on the air. Off-set, Butler pulled such stunts as stumbling onto David Letterman and claiming Walt Disney's last words were, 'Whatever you do, don't let the Jews get the place." (the sitcom aired on ABC, which had recently been purchased by Disney.) Butler's supporting cast soon grew tired of her expletive-filled rants and on-set breakdowns. Julie White quit the show, and Jon Paul Steuer reportedly left after he received a firsthand look at Butler's new boob job, which Butler proudly flashed about set. ABC hastily ended the show mid season in 1998.

Quentin was played by three different actors: Noah Segan in the pilot, Jon Paul Steuer in the first three seasons, and Sam Horrigan in the last two.

Many of Grace's former in-laws are named after famous Kellys in the entertainment world: Jean Kelly (a homophone for Gene Kelly), Emmett Kelly, DeForest Kelley, and of course, Grace Kelly.

Set in the fictitious town of Victory, Missouri.

In the first three seasons, Grace worked for the fictional petroleum company CBD Oil.