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The character of Dr. Neil Chase is based on John Edward Mack, M.D. (Oct 4, 1929 - Sep 27, 2004). A Pulitzer Prize-winning biographer and a professor of psychiatry at Harvard Medical School. Dr Mack was one of the most renowned proponents of alien abductions.

Both actresses playing abductees have connections to Doctor Who. Mare Winningham played Ellis Hartley Monroe in three episodes of Torchwood (a Doctor Who spin-off). Daphne Ashbrook played Dr. Grace Holloway in the 1996 Doctor Who tele-movie with Paul McGann as the Doctor.