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When it went off the air after one hundred seventy-one first-run episodes, this show had aired the most episodes of any medical programs, comedy or drama. Since then, only House (2004) (one hundred seventy-seven), Diagnosis Murder (1993) (one hundred seventy-eight episodes, plus five movies, plus pilot), Scrubs (2001) (one hundred eighty-two), Bones (2005) (two hundred forty-six), Frasier (1993) (two hundred seventy-five). ER (1994) (three hundred thirty-one), and Grey's Anatomy (2005) (three hundred forty-plus) had more episodes about health care practitioners.

In 1975, CBS considered cancelling the show, and Gunsmoke (1955) was up for renewal, but in the end, citing poor demographics, Gunsmoke (1955) end up getting cancelled, and the show ended up being renewed for one more season.