CBS was going to cancel the series after the first season. Lucille Ball used her power and influence to convince them to renew it for another season with the assurance that changes would be made. In the second season, Mannix was changed into a more hard-boiled independent private detective. The changes worked, and the series became a big hit running for eight seasons.
Mike Connors complained that this show was not very good at showing the consequences of violence. He said Joe Mannix would get thrown down a flight of stairs in one scene, and then appear without a scratch in the next.
Was the last television series to be produced by Lucille Ball and Desi Arnaz's production company, "Desilu."
Mike Connors reprised his role as Mannix on Hard-Boiled Murder (1997) of Diagnosis Murder (1993). It was a sequel to this show's Little Girl Lost (1973). Pernell Roberts and Julie Adams, who appear as guest stars in this show's episode, also reprised their roles on that show's sequel.
The role of Peggy Fair was intended for Nichelle Nichols, but she was forced to withdraw due to her commitment to Star Trek (1966).