In an interview in Fangoria magazine, screenwriter Anthony Harris stated that a good portion of the filmed material was improvised on the set and that the script was ignored.
Improvisation actor Del Close who appears as 'Hobo Wearing Eyepatch' would later play a much larger role as 'Reverend Meeker' in the 1988 remake of 'The Blob'.
In spite of having a stunt person on set, Robert Walker Jr. lobbied director Larry Hagman to do his own stunts for the rope climbing sequence in the finale. Walker had an acrobatic background, and was allowed to do the stunts.
Harris felt "Beware! The Blob" was too "funny" and not "scary enough" to be successful.
While still in production on "Beware! The Blob," writer and producer Anthony Harris was already preparing a sequel called "Curse of the Blob," but those plans were never implemented.