"Tweetie Pie" was the first cartoon to have its characters Sylvester and Tweety appear together (note: each of those characters had appeared in cartoons originally released before this one).
It was the first Warner Bros. short to earn an Oscar for Best Animated Short.
Robert Clampett was originally working on his own Tweety and Sylvester pairing short before he was fired. The storyboard produced (which would've been titled "The Fat Rat and the Stupid Cat") depicted Tweety living in a bird cage, which possibly marked his transition from a wild baby bird to a domestic canary. By the time Bob Clampett left Warner Bros. in 1945, however, the project ended up sitting and never entered full production. Meanwhile, Warner Bros. producer Edward Selzer wanted the woodpecker from Peck Up Your Troubles (1945) to be paired again with Sylvester in a follow-up director Friz Freleng was already producing but when Freleng wanted to replace the woodpecker and pair Sylvester with Tweety instead, Eddie Selzer objected and Friz Freleng threatened to quit. Later that evening though Selzer apologized to Freleng and later allowed Tweety to be used for his short. Production would be being around the time of the release of A Gruesome Twosome (1945) in June 1945, the final Tweety short directed by Bob Clampett and released a month after he left Warner Bros.. Later, he went to work on to create one Charlie Horse short and later became a television personality for creating Beany in 1949.
The name Thomas might have been a jab at rival cartoon feline Tom, of MGM's "Tom and Jerry."
The first Warner Bros. cartoon to had been a declared for an awards program by the Academy of Motion Picture Arts and Sciences.