(at around 8 mins) When Gabrielle first jumps out of the plane she is shown not wearing goggles. But seconds later she is shown wearing them.
Almost all facts about science are 'set aside' for this film.
The pirate ship at Las Vegas' 'Treasure Island Hotel & Casino' cannot be sailed on water, it was built for display and entertainment only.
Though it's played for homage to 'The Wizard of Oz', a built house cannot still remain in one piece being in a tornado for a long period of time.
As April's character is homage to 'The Bionic Woman', the scientific facts (with rebuilding a dead person as robotic and so forth) are all 'set aside'.
Throughout the franchise, the sharks eat a few people whole --without chomping down on them. In reality, sharks don't have a throat big enough to do that (which is a reason for their rapid biting). This species is imaginary, they can depict whatever the filmmakers want.
Throughout the franchise, the CGI is poor. [It has been explained by the filmmakers that viewing it requires a strong 'suspension of disbelief']
In this instalment, famed host Al Roker appears in one piece (with no injury seen), though in the previous instalment he appeared to get mauled by a shark. With close inspection on the attack in that film, he mostly has his arm up when the shark attacks (it wasn't right on his head). Also, considering that five years passed since the last one, that's plenty of time to get normal.
(at around 26 mins) Aston proposes blowing up part of the Grand Canyon to block the flood from Hoover Dam. The Grand Canyon is over 50 miles upstream from Hoover Dam.