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At the age of 11 she visited a theatre and became obsessed with it. One of her stepsisters, then a student at the Saint Petersburg medical university, was offered to play a small part in Konstantin Stanislavski's play. She brought Serafima a signed photo of him and suggested to enter the Moscow Art Theatre.

Serafima Birman was a Soviet and Russian actress, theatre director and writer.

In 1969 Birman's husband Alexander Talanov, a Russian writer and journalist, died of illness aged 68. Serafima took his death hard. She soon became mentally ill and left the theatre. She was taken by her relatives to Leningrad where she went through treatment in mental hospitals until her death in 1976.

She People's Artist of the RSFSR (1946).

While biographers usually state the couple was childless, according to the actor Stanislav Sadalsky Birman actually left some descendants.