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She is fluent in French and Italian.

Nominated for the 2009 Tony Award for Best Performance for a Featured Actress in a Musical for "Billy Elliot".

She is an Olivier Award-nominated British actress.

Received her second and third Olivier nominations for performances in two more musicals in London's West End: 'The Three Penny Opera' and 'Women on the Verge of a Nervous Breakdown'.

Has 2 sons with her husband Jason Phipps: Orlando, born in 1997; and Cain, born in 2000 as Harrison before legally changing his name at 17.

She played county level tennis before studying sociology at the University of Nottingham,.

A memorial service was held for her at St. Paul's Church, Covent Garden on 6th May 2024.

Gwynne undertook voluntary work for the charity Sightsavers International, a group committed to combating blindness in developing countries.

She was nominated for the 1992 BAFTA TV Award for Best Light Entertainment Performance for the comedy series Drop the Dead Donkey (1990-1991), and won the 2009 Drama Desk Award for Outstanding Featured Actress in a Musical for her role in the Broadway production of Billy Elliot the Musical.

In August 2014, Gwynne was one of 200 public figures who were signatories to a letter to The Guardian opposing Scottish independence in the run-up to September's referendum on that issue.

Gwynne became an actress in her mid-twenties. In her first prominent television role she played feminist lecturer Dr Robyn Penrose in the BBC television mini-series dramatisation of David Lodge's Nice Work in 1989.