- To prepare for the role of Max Taber in One Flew Over the Cuckoo's Nest (1975), he resided in a mental institution for several weeks and studied the patients. He modeled his character after one of the patients and remained in character through the filming, even when not on screen.
- A devoted bicyclist, he once rode through Italy, pedaling from Milan to Venice, over the Dolomites, along the Amalfi coast and to Naples.
- For his brief 1985 scenes in बैक टू द फ़्यूचर (1985), he wore prosthetic make-up to appear 30 years older than in his 1955 scenes, which dominate the film. In the sequels, the 1985 Doc Brown has more scenes. To avoid having to put him through extensive make-up every morning, writers Robert Zemeckis and Bob Gale came up with the idea of Doc Brown visiting a rejuvenation clinic in the future, which results in his face looking much younger.
- In Man on the Moon (1999), he appears as himself reprising his old role of Rev. Jim Ignatowski in many scenes from Taxi (1978), 20 years after the sitcom had aired.
- Has appeared in over 200 plays, including many on Broadway, in regional and summer-stock productions.
- As a young actor, he performed at the Yale Repertory Theater with Meryl Streep.
- Attended and graduated from Staples High School in Westport, Connecticut (1958).
- Attended the prestigious Fessenden School in West Newton, Massachusetts.
- At age 19, he moved to Manhattan and began studying with acting teacher Sanford Meisner at the Neighborhood Playhouse School of the Theatre.
- His Taxi (1978) character, Rev. Jim Ignatowski, was a huge fan of Star Trek (1966). Lloyd went onto play Klingon Commander Kruge in Star Trek III: The Search for Spock (1984).
- In a scene in बैक टू द फ़्यूचर (1985), his character Dr. Emmett L. "Doc" Brown, hangs on the arm of a large clock. This mimics a stunt done by Harold Lloyd (no relation) in Safety Last! (1923).
- Younger brother of Sam Lloyd Sr..
- Is the youngest of seven children of Ruth (Lapham) and Samuel R. Lloyd. Many of his family lines are Colonial American (English), with deep roots in Vermont, Massachusetts, and Rhode Island. His paternal great-grandmother, Francis Augustine Felix, was born on Cuba, to American parents, of partly French ancestry.
- Grew up in Fairfield County's New Canaan, Connecticut.
- His maternal grandfather, Lewis Henry Lapham (1858-1934), was an entrepreneur who made a fortune consolidating smaller business in the leather industry. He was also one of the founders of Texaco Oil Company.
- Attended and graduated from the Darrow School, whose alumni include Chris 'Mad Dog' Russo, Gregory Hughes and photographer Jane Feldman.
- His maternal uncle, Roger Dearborn Lapham (1883-1966), was chairman of the American-Hawaiian Steamship Company (mid-1920s). He also served as the 32nd mayor of San Francisco from 1944 - 1948.
- During the making of the black comedy mystery film Clue (1985), Christopher Lloyd, Martin Mull, Michael McKean and Lee Ving would often spend time on the Billiard Room scenery playing pool. Eileen Brennan also would occasionally stopped by to watch and cheer everybody on.
- Has admitted to initially not getting along with Michael J. Fox who replaced Eric Stoltz in बैक टू द फ़्यूचर (1985) as Marty McFly. After shooting for many weeks with Stoltz when producer Bob Gale and director Robert Zemeckis announced Stoltz was to be dismissed and replaced by Fox, Lloyd admitted he was the only one to object to the decision as opposed to Tom Wilson, who did not get along with Stoltz on account of extreme method acting. While the filmmakers and Wilson welcomed Fox with open arms to the movie scenery, Lloyd remained aloof and distant with Fox initially not wanting to reshoot most of the scenes and feeling that Stoltz was fine as Marty. However, after enough time filming with Fox, Lloyd warmed up to him knowing he had a special chemistry with fox that cannot be replaced. Naturally, Lloyd later admitted he was wrong and Fox was the best choice for Marty, and working on three films, they became close friends and remain so to the present day. Lloyd admitted his stubbornness and resistance to Fox was a huge mistake and he has continued to be a very loyal friend to Fox and supported him through his battle with Parkinson's disease, which Fox was diagnosed with after the filming of बैक टू द फ़्यूचर: पार्ट III (1990) was finished.
- In a June 2009 interview, he said that the role of Klingon Commander Kruge in Star Trek III: The Search for Spock (1984) was one of his favorite roles. He compared Kruge to the role of Judge Doom in रोजर रैबिट को किसने फंसाया (1988), both being overly evil characters he considered "fun to play".
- In बैक टू द फ़्यूचर: पार्ट II (1989), many series from the 1980s are featured on the televisions inside the Cafe 80's, including sitcoms Family Ties (1982) and Taxi (1978), which originally starred Michael J. Fox and Christopher Lloyd, respectively. Also in the movie, the date on the 2015 USA Today newspaper is October 22, this is Christopher Lloyd's birthday.
- During the making of Star Trek III: The Search for Spock (1984), he did not completely understand using communicators to send messages. He would often shout his lines into the air rather than speak into his communicator. He was ordered several times not to shout at the sky.
- He was offered the role of burglar Harry Lyme in Akela Ghar (1990), which John Hughes had written and directed. Lloyd declined the role, which then went to character actor Joe Pesci. Lloyd regretted his decision to decline the film after its massive success, and informed Hughes he was willing to appear in another subsequent film for him. Hughes then wrote the role of Switchblade Sam for Dennis the Menace (1993), hoping that Lloyd would play the role, and Lloyd immediately accepted.
- Has worked with Peter Weller in the cult movie The Adventures of Buckaroo Banzai Across the 8th Dimension (1984). Both stars appeared in the very popular Star Trek series. Lloyd appeared in Star Trek III: The Search for Spock (1984) and Weller appeared in Star Trek Into Darkness (2013).
- Has appeared with Danny DeVito in three films: One Flew Over the Cuckoo's Nest (1975), Goin' South (1978) and Man on the Moon (1999); and Mary Steenburgen in three films: Goin' South (1978), बैक टू द फ़्यूचर: पार्ट III (1990) and Wish You Were Dead (2001).
- Has appeared with Anjelica Huston in five films: One Flew Over the Cuckoo's Nest (1975), The Postman Always Rings Twice (1981), The Cowboy and the Ballerina (1984), द एडम्स फैमिली (1991) and Addams Family Values (1993).
- He has appeared in three films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically significant": One Flew Over the Cuckoo's Nest (1975), बैक टू द फ़्यूचर (1985) and रोजर रैबिट को किसने फंसाया (1988).
- He was the visual inspiration for Gru, the main character of डेस्पिकेबल मी (2010) and its sequels, after he played Fester Addams in द एडम्स फैमिली (1991). He was 72 years old at that point. He was also the visual inspiration for Dru, Gru's long-stranded brother, in Despicable Me 3 (2017), after he played Fester Addams again in Addams Family Values (1993).
- In 2018, he played a traffic officer in a commercial for FIAT Automobiles, but this is a reference to the role of Dr. Emmett Brown, as the commercial is about an automobile that represents the future. The commercial also features time-travel elements and uses the original iconic Back to the Future score.
- In March 2022, he appeared alongside stars Ryan Reynolds and Mark Ruffalo as an expert offering what time really means in a public service announcement promoting the film The Adam Project (2022) on the streaming service media provider Netflix.
- His former house in Montecito, California was destroyed in the Tea Fire of November 2008.
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