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Missi teamed up with fellow actress Shawnee Smith, of the Saw franchise and Becker (1998), to start the band Smith & Pyle. The band tours regularly throughout California and the West Coast as well as performing at conventions for fans. They are a smooth blend of southern rock and sarcasm.

Trained in Taekwondo.

Was scheduled to ring the closing bell of the New York Stock Exchange on September 29, 2008 - a day when the Dow Jones industrial average dropped 778 points - but decided not to so as to "let the day be about the market and not about having a celebrity ring the bell".

Attended the North Carolina School of the Arts in Winston-Salem, North Carolina.

In 2004, she received an MTV Movie Awards "Best Fight" nomination alongside Queen Latifah for the film Bringing Down the House (2003).

Casey Anderson's 800-pound grizzly bear, Brutus, which he raised since it was a baby, was a guest at their wedding. The couple wed on September 12, 2008 in Montana.

In the mid-1990s, she played the "black widow" character at the interactive theme restaurant, Jekyll and Hyde, in New York City.

Attended and graduated from Germantown (Tennessee) High School (1991) (where Chris Parnell graduated (1985)). She appeared in the school's GHS-TV cable access station and Poplar Pike Playhouse Theatre.

She has four older siblings: Debbie Pyle, Julie Pyle, Sam Pyle and Paul Pyle. She also has half-siblings Gordon Pyle and Meredith Pyle.

Ranked #98 in Maxim magazine's 100 Hot Women of 2004 list.

Her maternal grandmother was the daughter of Swedish immigrants.