- Was managing editor of "Vanity Fair" magazine from 1932-1934.
- Conceived "Life Magazine", which her husband Henry Luce would publish with great success.
- Warned FBI about the attack on Pearl Harbor. They unfortunately did not believe her.
- Clare Boothe Luce was appointed U.S. Ambassador to Italy by President Dwight D. Eisenhower in 1953, and served until 1956.
- Is credited with being the first to discover Russian missiles in Cuba in 1962, through her private surveillance efforts.
- Husband Henry Luce was the founder and publisher of Time magazine.
- Republican US Congressional representative from Connecticut, 3 January 1943-3 January 1947. Was not a candidate for renomination in 1946.
- Had lifelong love affair with Bernard Baruch.
- Her hobby was doing jigsaw puzzles.
- Was Time magazine's war correspondent during World War II.
- After graduating from high school at 16, Clare left home and found a job with a company that manufactured paper novelties.
- Announcing the nominees for Best Director at the Oscars in 1952, Luce did not know how to pronounce John Huston's name. She said, "and - and - is it John Huss-ton or John Hoo - ston?".
- Biography in: "The Scribner Encyclopedia of American Lives". Volume Two, 1986-1990, pages 557-559. New York: Charles Scribner's Sons, 1999.
- Inducted into the Connecticut Women's Hall of Fame in 1994.
- Devout convert to Roman Catholicism.
- A fictionalized portrayal of her appears in the musical "Little Shop of Horrors" during the song "Meek Shall Inherit.".
- Among her works was the theatrical black comedy "Margin for Error" (1939) which focused on the mysterious death of a diplomat from Nazi Germany. The initial main character (the diplomat) had found himself surrounded by personal enemies, disloyal subordinates, and obnoxious allies. So he had a master plan which would eliminate several of these people, would frame some of them for crimes, and would blackmail the rest into obeying him. When he dies before his plan's scheduled start, nearly everyone has a motive for killing him, including the police officer who is contacting the investigation. The play is partly a whodunit, and partly a political satire.
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