In an interview with the Hollywood Reporter, Zach Cregger clarified that he isn't interested in directing scripts written by other people, as he wants to be personally involved with the writing process of everything he works on. While this stance might change down the line, it exhibits an admirable brand of conviction/commitment, which might be the key to a film that will break the so-called "video game adaptation curse" that the franchise has suffered so far. When asked about his "Resident Evil" movie, Cregger said:
"That's an original screenplay, by the way. It's a weird story. I wrote it, and I love the story. It has nothing to do with any of the other 'Resident Evil' movies. If I do my job, it will feel fresh and edgy and weird [...] I have 'Resident Evil', and then I have a sci-fi movie right after that's original [...] Then I have another one that I'm working on that feels like 'Nightcrawler'. But all of those are original. My agents don't even send me scripts, because I'm not going to direct other scripts. I'm in a very fortunate position to be able to write a movie and have a good shot at getting a movie made, [so] why would I not do it if I like to write?"
Robbie Amell stated he hoped to return as Chris Redfield in the Resident Evil: Welcome to Raccoon City sequel that included his boulder-punching scene from Resident Evil 5. By June 2022, Tom Hopper confirmed Sony and Constantin Film were pleased with the film's success on video-on-demand and said he hoped to play Albert Wesker again.
Director Johannes Roberts stated that if a sequel to Resident Evil: Welcome to Raccoon City were to be developed, he would like to adapt the story from Resident Evil - Code: Veronica with the referenced in the film with an appearance of the Ashford Twins and then Resident Evil 4. He also expressed interest in adapting Resident Evil 7: Biohazard and Resident Evil Village in the future.
Zach Cregger pick to direct the reboot and have to dropped out of directing Clue after he was hired a week early.
Australian internet digital artist Kode Abdo better known as BossLogic made an art photo of actor Antony Starr as Albert Wesker, Starr himself even agree on interesting to play Wesker.