Olivia Wilde was cast, but then got pregnant. Director Reed Morano's response was to postpone filming, thinking that becoming a parent would only benefit the film.
Director Reed Morano dedicated this movie to her late father. In the end credits she remembered him "...as if it were yesterday we met last..."
Olivia Wilde smokes DMT in this movie. In Lazarus Effect (2015), she and other scientists discuss its possibilities.