Dr. Amy Larsen, a Chief of Internal Medicine, suffers a brain injury. Despite this setback, she remains resolute, determined to practice medicine again while navigating new challenges that arise.
While recovering in the hospital, Amy can't resist getting involved in her roommate's case, leaving the doctors and nurses to adapt to the former formidable chief now being in the role of a patient.
Amy, allowed to return to work under strict guidelines, teams up with TJ to treat a patient suffering from mysterious liver problems. Sonya and Jake help an elderly couple navigate the final chapter of their love story.
Amy confronts who she has become after a family tragedy seven years ago. Meanwhile, Sonya and TJ clash over treating a sick Marine, and Amy and Jake uncover a life-changing truth about an Alzheimer's patient.
Amy and Sonya struggle to help a teen patient in need of a bone marrow transplant and his younger brother whose own health issues jeopardize his ability to donate. Jake deals with a fainting bride and her anxious groom.
Larsen visits her old home but remembers nothing. She proposes her daughter live with her, but Michael hesitates. She treats a girl with glass in her hand who felt no pain, while Allen sees a demanding patient seeking tests.
Larsen returns to work and faces a difficult case involving her protegé's father. Meanwhile, two colleagues race against time to help a single mother keep her child while dealing with her medical condition.
