The film took 4 years to complete as they only worked weekends.
During filming, a serious accident occurred that nearly caused the death of Bianca Bradey's stunt double, she undershot her jump from the back of the lab truck onto the bonnet of the zombie truck and was nearly run over, fortunately she was unharmed.
A poster of Wyrmwood appears in Season 2 Episode 8 of Z Nation during a conversation between The Collector and Murphy about the movie White Zombie.
The film served as the basis for one of the mazes at the 2015 Fright Nights event at Warner Brothers Movie World on the Gold Coast, Queensland
Producers couldn't afford guns so the props team cut wood boards into gun stock shape and put a black pipe on top to look like gun barrel. They then attached a bolt to resemble a cocking mechanism