Reportedly, James Bond actor Daniel Craig personally hand-picked Cuban actress Ana de Armas to play Paloma in this Bond movie, after working with her on À couteaux tirés (2019), which first released about only four months before No Time to Die was originally meant to release.
Ana de Armas (Paloma) was so worried that her action sequences would not be good enough with only three weeks of training, she has shared "I kept telling Cary, 'I just have three weeks of training' and I said it so many times he said, 'Say that in the movie.'". Her line to Bond that she had had been "training for three weeks, more or less", was kept in the final version.
Daniel Craig has said that he would retire from the role of James Bond if he felt he was too old to play the character. Craig has also said that it has become harder to be fit enough for the role and that there has been more use of doubles for action sequences.
In January 2021, a number of brand sponsors and partners demanded re-shoots pertaining to their product placement. Some products seen in the movie became outdated or obsolete due to the eighteen months delay caused by the global health pandemic. Reportedly, the Nokia phone ad starring Nomi (Lashana Lynch) had a smartphone which became both outdated and obsolete during the wait. The speed at which smartphones get new models and releases is particularly fast. In the relevant Nokia tie-in commercial, CGI was used to replace the phone in the advert, but the original smartphone in the movie remained the same.
The porcelain Royal Doulton "Union Jack" bulldog statuette which M (Judi Dench) gave James Bond as a present in 'Skyfall' (2012) can be seen just before James Bond (Daniel Craig) uncovers his Aston Martin V8 Vantage in his garage. The British Flag Bulldog figurine is seen at the bottom right corner of the screen.
Michael G. Wilson: Uncredited, the long-time series producer appears as a Military Officer at the SPECTRE party in Cuba, when James Bond walks through the meeting. Wilson has made a cameo in every Bond movie since L'Espion qui m'aimait (1977).