Several of the characters in the fictional story were pivotal in reforming Japan during the Meiji Restoration.
Based on the manga "Jin" by Motoka Murakami (published by by-weekly manga magazine Super Jump from 2000-2010).
Minakata Jin is often referred to as practicing Dutch medicine. Also known as rangaku, was a different practice to Japanese medicine of the era. Rangaku was learnt via a Dutch trading post notable for being the single place of direct trade and exchange between Japan and the outside world during the Edo period.