Venkat Prabhu initially titled the film as Enga Area Ulla Varaadha (Don't come into our territory), but lyricist Vaali was critical of the idea, feeling that the title was "negative" sounding. Subsequently, the film was renamed as Chennai 600028, with the idea of including the area's postcode taken from the title of the American television series Beverly Hills, 90210.
Famous director Pa.Ranjith, who worked as an assistant director in this film, appears in a scene playing cricket.
Chennai 600028 is the directorial debut of Venkat Prabhu.
The success of the film gained the relatively unknown actors Jai, Shiva, Premji and Nithin Sathya, newcomers Vijayalakshmi, Vijay Vasanth and the director Venkat Prabhu popularity.
The film's title is derived from the pincode for Mandaveli, a suburb of Chennai, where the story takes place.