Peter Outerbridge, who plays Father Keegan, originated the on-screen role of William Murdoch in the three made-for-television movies collectively known as The Murdoch Mysteries (2004).
In episode 2 of season 2, Inspector Brackenreid says he is from Doncaster, England. In real life, Thomas Craig who plays the inspector was born in Sheffield; the two places are only 25 miles apart.
The fictional newspaper The Toronto Gazette, seen in the opening credits, was also the fictional newspaper of the 1980s CBC contemporary mystery series Seeing Things.
Many guest actors have returned to the series in a subsequent episode playing a new and completely unrelated character.
Many of the techniques used by Detective Murdoch to solve crimes weren't available in his time. In fact, many of them wouldn't even be available for another 70-80 years from the time period the story is supposedly taking place, thus the premise that such innovations were invented or inspired by the characters of the show.