Red Hot Chili Peppers filed a lawsuit on November 19, 2007 against Showtime Networks over the name of the series, which is also the name of the band's 1999 album and hit single. They state in the lawsuit that the series "constitutes a false designation of origin, and has caused, and continues to cause, a likelihood of confusion, mistake, and deception as to source, sponsorship, affiliation, and/or connection in the minds of the public." Showtime Networks argued that the band did not in fact create the term Californication. They point out that the term appeared in print in Time magazine in 1972, while show producer, Tom Kapinos, cites the inspiration as coming from a bumper sticker he saw in the '70s that read, "Don't Californicate Oregon." The lawsuit was settled out of court.
White Famous (2017), a TV series that premiered in October 2017 and was co-created by Californication's creator Tom Kapinos, features some secondary characters first introduced on Californication, such as Stu Beggs (played by Stephen Tobolowsky) and Kali (played by Meagan Good).
Simon Spotlight Entertainment published the book God Hates Us All, which is sold with Hank Moody as author, on the 15th of September 2009
In 2014, GQ magazine listed Eva Amurri's stripper scene as the 3rd most underrated nude moment in TV history. They also pointed out how they love that she carried on the tradition of showing off her impressive natural breasts started by her mom Susan Sarandon.
Pamela Adlon revealed in an interview that during an episode in the final season, she was seen lying on a bed in panties when her underwear shifted enough to show the lips of her vagina. It was an accidental exposure producers left in the show.