The cast includes several actors who appeared in the TV series Buffy the Vampire Slayer: Clare Kramer (who appeared as the god-like Glory)l; Tom Lenk (who played would-be supervillain Andrew); and Serena Scott Thomas (who played Faith's evil mentor, Gwendolyn Post). Although Adam Baldwin didn't appear in that series, he had a recurring role in the spin-off show Angel.
Matt Keeslar was in Scream 3. Jeremy Sisto was in Wrong Turn. Ellie Cornell was in HALLOWEEN 4 and 5, and House of the Dead 1 and 2. Charlotte Ayanna was in The Rage: Carrie 2 and Jawbreaker. Also, Alan B. McElroy wrote Halloween 4 and Wrong Turn. The Thirst was produced by Ellie's husband Mark Gottwald who has a cameo.