The last Pokemon game to use the tagline "Gotta catch 'em all!"
The Japanese version had an ability to port with cell phones to allow online play. This is the earliest example before it would become fully included in Pokémon Version Diamant (2006) and Pokémon Version Perle (2006).
Although Pokémon Gold and Silver are compatible with all Game Boy models (original up to the Game Boy Advance SP), Crystal will not work on models prior to the Game Boy Color. This is due to the cartridges being of different models.
The first Pokemon game where players could play as a female trainer.
The first Pokemon game to have animated sprites for Pokemon upon entering battle and checking their profile.