When Ray and Claude are standing on a box of bottles, Claude mentions that a one of his toes has slipped into one of them. This actually happened during the take, but Martin Lawrence kept going, despite Eddie Murphy's laughing, which is genuine.
Of all the movies on which Eddie Murphy and makeup artist Rick Baker collaborated, Perpète (1999) is the only one where Murphy did not play more than one character. Baker only used the makeup to age Murphy's character in this movie.
When Rayford (Eddie Murphy) is getting beat up in a fight, he says: "I know a bitch named Della who hits harder than you." This is a reference to Les Nuits de Harlem (1989), in which Murphy's character is beat up in a fight with a madam played by Della Reese.
Spanky's (Rick James) limp was not acting. The scene was shot after Rick James underwent hip replacement surgery.