Both the Romy and Michele characters were originated in the stage play "Ladies Room." Lisa Kudrow reprises the role she played in it.
Alan Cumming owns a bar in New York City called Club Cumming where every Saturday the bar hosts a Romy and Michele themed day involving 90s music, DJ requests written on Post-It notes, and scarf folding stations.
Lisa Kudrow received a degree in Biology from Vassar College, and Mira Sorvino a degree in Asian Studies from Harvard University, so during production of Romy and Michele, they nicknamed each other "Smart" and "Smarter."
The arrowhead symbol on Romy's blue dress bears a striking resemblance to the logo for the Star Trek franchise. Mira Sorvino specifically chose this since she is a huge fan of the original Star Trek series.
In one of the high school flashback scenes, popular mean girl Christy played a trick on Michele by putting magnets on her back brace. Julia Campbell, the actress who played Christy, developed scoliosis at age 11 and actually wore a back brace in real life. At 15, she had to have corrective surgery when her spine started cutting into her right lung. She has since recovered but cannot partake in any physical activity that puts pressure on her spine.