Anecdotes

Despite the movie's subtitle, ticks aren't insects. They're arachnids, more closely related to spiders and scorpions.

Midway through filming, an earthquake in the San Bernardino mountains destroyed the mountain location and the hotel the cast and crew stayed at. The cabin had to be recreated in a wooded area in the Griffith Park golf course and could only be used in the evenings so as to not obstruct golfers during the day.

David Gale had originally been cast as the heavy, but died a year before production started.

During a Q&A at Dragon*Con in 2008, Ami Dolenz said that one of her main memories of making the film is the fake blood, which would stick to her skin and hair.

Special FX creator Doug Beswick wrote the original screenplay two decades earlier under the title "Cycle of Blood."