The apartment hallway and rooms were sets that were built inside of a warehouse in Los Angeles.
In a 2024 interview with ComingSoon, Josh Forbes spoke about how the main character ended up a prog rock musician: "I mean, to me, a big inspiration is the movie Inside Llewyn Davis (2013) by Ethan Coen & Joel Coen, where you have a guy who is destroying everything around him in a way. He's throwing everything away for his dream, and his dream is to be a folk musician. So it was kind of similar to that, and in one of the earlier versions of Destroy All Neighbors, Jonah Ray's character was a cartoonist, but when one of writers came on, Mike Benner, he had the great idea of, like, 'we have Jonah and he's a musician, he should do music'. And for me, it was then, 'What's the kind of music where even if you're the best at it, nobody will give a s**t about it?' And prog, if you were a prog guy now... You won't be getting free coffee at Starbucks or whatever. I have that feeling working on a movie like this and being so in love with these things that are so dorky, I pin so much of my happiness on 'Oh, if I can achieve this, I'll be happy'. This is a cartoon version of that, and William, he has to learn to just enjoy the things he's doing, because even if he succeeds, that's not gonna be enough to sustain him, if that makes sense."