According to Freddie Highmore, he was initially turned down for the role of Shaun Murphy. The producers told him they wanted someone who was at least 25, and he replied: "But I AM 25."
Richard Schiff (Dr.Glassman) and Sheila Kelley (Debbie Wexler) have been married in real life since 1996.
Nicholas Gonzalez (Dr. Neil Melendez) comes from a medical family. His father and brother are both surgeons and his mother is a bookkeeper at South Texas Radiology in San Antonio. His brother acted as an uncredited medical consultant to him on set.
All three of the actors playing the surgical residents were born in London, UK. Freddie Highmore and Antonia Thomas both use American accents, while Chuku Modu speaks naturally.
Dr. Alex Park (Will Yun Lee) and his wife Mia Wuellner (Jennifer Birmingham Lee) are a couple off-screen.