Director Paul W.S. Anderson and the crew traveled to remote locations in South Africa and Namibia to capture the film's expansive vistas.
Director Paul W.S. Anderson cast his wife Milla Jovovich as the lead in Monster Hunter following the success of their previous collaborations on the Resident Evil film series. This was the sixth time Anderson directed Jovovich in leading roles, after four Resident Evil films and one Three Musketeers movie.
Tip 'T.I.' Harris says that his youngest son convinced him to hop on board, because he is a fan of the video games.
Captain Artemis Milla Jovovich is billed as a U.S. Army Ranger. She has a tattoo on the right side of her neck that reads RLTW, which means Rangers Lead The Way.