Listed on the 2016 "Blacklist" a list of the best unproduced scripts of the year.
In December 2017, a fierce bidding war for the distribution rights of the film, which was between Amazon Studios, Universal Pictures, and Paramount Pictures, concluded with Amazon Studios winning the rights with a $10 million dollar plus bid.
During the writing of the film, Dan Fogelman listened to Bob Dylan's album Time Out of Mind and in particular the song Love Sick, which opens the film. Written after the divorce of the singer of his second wife, this double album, dating from 1997, speaks of love and mourning with melancholy.
Life Itself ... takes place on two different continents and in two distinct languages, English and Spanish. Dan Fogelman admits to being paralyzed by the challenge that this represented.
Will (Oscar Isaac) mentions doing a marathon of Natalie Portman movies. Isaac played her on-screen husband in Annihilation (2018).