Dr. William Burroughs is named after writer William S. Burroughs. As Rose is healing from the procedure, Dr. Burroughs actually listens to a recording of "Advice For Young People", in which the author William S. Burroughs talks about psychic vampires: "If, after having been exposed to someone's presence, you feel as if you've lost a quart of plasma, avoid that presence. You need it like you need pernicious anemia. We don't like to hear the word 'vampire' here. Trying to improve our PR. 'Interdependence' is the keyword. Enlightened interdependence. Life in all its rich variety. Take a little; leave a little. However, by the inexorable logistics of the vampiric process, they always take more than they leave."
The photo of Burroughs' wife is of a 1970s Lynn Lowry - the lead actress of David Cronenberg's first film Frissons (1975).
Producer Paul Lalonde is most known for his Christian films, including Left Behind (2000) starring Kirk Cameron as well as the remake Le chaos (2014) starring Nicolas Cage. Rabid (2019) marks his first non-religious project.
Wrestler CM Punk (credited as Phillip Brooks) plays Billy, the guy pleading with the bouncers for them to let him go back into the nightclub. His wife A.J. Mendez (credited as April Mendez), better known as wrestler A.J. Lee, plays Kira, the model with the glass of champagne talking to Chelsea backstage at the fashion show.