Mika Abdalla, Ysa Penarejo, and Genneya Walton have all previously starred in "American Girl" movies.
The series (and toy line) is about getting young girls interested in STEM (science, technology, engineering, mathematics) fields. Danica McKellar, who plays The Quail (the leader of NOV8), is a mathematician, namesake of the "Chayes-McKellar-Winn theorem", and a best-selling math-book author.
In season 5, Maddie replaces Alyssa Lynch in the role of Devon D'Marco.
The girls go to Maywood Glen Academy, which is abbreviated as MGA. MGA Entertainment is the name of the company that owns the Project MC2 property.