Anecdotes

Had a strained professional relationship with Jon Stewart after Stewart's impersonation of presidential candidate Herman Cain on an episode of the Daily Show. Wyatt took offense to it, claiming it sounded like the character "Kingfish" from the Amos N' Andy Show, and when he confronted Stewart with his objection to the impression, Stewart became upset and stormed out of the room after berating Cenac. This led to Cenac leaving the show, but they appeared to patch things up in time for Stewart's last show as host of the Daily Show, in which Cenac made a cameo appearance.

Colin Quinn was a huge influence on his career. Wyatt Cenac left college for a year when he was 19 to intern at Saturday Night Live (1975). While Cenac was interning, Quinn took him under his wing and encouraged him to start comedy writing.

In 2009, Wyatt Cenac was a guest writer for Marvel comics.

Auditioned to play Barack Obama on Saturday Night Live (1975) but lost to Fred Armisen.

Wyatt Cenac was cast in the movie Medicine for Melancholy (2008) after the director, Barry Jenkins, watched him on YouTube, then tracked him down on Myspace.

Wyatt has tattoos on both arms.