- Is fluent in Catalan, English, French, Spanish and German.
- He was raised trilingual (German, Catalan and Spanish).
- Being a pacifist, he was a conscientious objector and did civilian service.
- Was born in Barcelona to a Spanish mother and a German father. Said in an interview that the reason he was born in Spain was that his mother didn't trust German hospitals and the family returned to Cologne soon after his birth. He spent a lot of his summers in Barcelona though.
- Daniel's father was German director Hanno Brühl, who was born in São Paulo, Brazil. Daniel's mother is Spanish.
- Used to be in a band called Purge, he was the singer.
- Started his acting career at the age of 4 when he frightened his mother by playing a dead man or fainting theatrically.
- Broke Will Smith's world record for most public appearances on the red carpet in 12 hours together with Jürgen Vogel by attending the premiere of their movie Un ami à moi (2006) in Munich, Berlin, Hamburg, Düsseldorf and Cologne (22 October 2006).
- Brühl, Leonardo DiCaprio, Tilda Swinton, Marion Cotillard, Emma Thompson, Tom Hanks, Jake Gyllenhaal and Amy Adams are the only actors to receive a Golden Globe, SAG, BAFTA and Critics' Choice Award nomination for the same performance and then fail to be Oscar-nominated for it: for their performances in Rush (2013), Les Infiltrés (2006), We Need to Talk About Kevin (2011), De rouille et d'os (2012), Dans l'ombre de Mary : La Promesse de Walt Disney (2013), Capitaine Phillips (2013), Night Call (2014) and Premier contact (2016), respectively.
- Has a two sons, Anton Hanno (b. 2016) and (Son b. 2020).
- Jessica Schwarz gave him the nickname "Gollum" because he looks like the character on Le Seigneur des anneaux : La Communauté de l'anneau (2001) when he wakes up in the morning.
- Nominated for the 2019 Golden Globe Award in the Best Performance by an Actor in a Limited Series or a Motion Picture Made for Television category for his role as Laszlo Kreizler in The Alienist (2018), but lost to Darren Criss for American Crime Story (2016).
- 2003: Named as one of European films' Shooting Stars by European Film Promotion.
- Was formerly engaged to Jessica Schwarz from 2001 to 2006.
- Brühl's starring role in Otages à Entebbe (2018) marked the second time he has acted in a film with a title that started, "7 Days in..."--the first was 7 jours à la Havane (2011).
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