David Hyde Pierce

Holds the record for being nominated for most Best Supporting Actor Emmys for a character, "Dr. Niles Crane" on Frasier (1993). He was nominated 11 times.
He received his initial interview with the creators of Frasier (1993) due to his close resemblance to Kelsey Grammer. After the interview, the part of Niles Crane was written for him.
One year when he was performing at the international comedy festival "Just for Laughs", he arrived in Montreal for check-in with the festival exhausted and disheveled. He remarked to one of the festival workers how he was looking forward to resting in his hotel room. The worker replied with empathy, saying how tired they were working overtime with few breaks trying to tie up the loose ends and help the performers before the comedy routines. Moments later, Pierce returned with fresh coffee and pastries for all those working at the Festival's check-in.
Is active in the fight to find a cure for Alzheimer's, which his grandfather suffered and died from. His father also suffered from the disease but died from pneumonia.
Attended Yale with Jodie Foster. When she was preparing to direct Le petit homme (1991), she remembered him from a play he was in at that time and called and offered him a part.

I can vividly recall telling a joke in, like, second grade and realizing it was funnier if I didn't laugh. I've been deadpan ever since.
My life is an open book, but don't expect me to read it to you.
[Speaking on "The View" on May 28, 2009, about his activism for same-sex marriage] I've been going [to marriage-equality rallies] because I had the experience of...having this private thing [marriage] suddenly dragged out into the public and having people I don't know take a vote--I mean, can you imagine? If you're married, the people in your state getting together and saying, "well, you know what, you're not." It's a very odd thing. And I understand all the religious and emotional issues that are involved, but I don't...it was a very angry-making feeling, both in November when it was taken away from me and this past Tuesday, sitting in front of my television wondering, "gee, I hope the Supreme Court thinks it's okay for us to be married." Excuse me--it's none of your business.
[on Slim The Walking Stick in Pixar's A Bug's Life] He was me and better than me. And he was more than me because he has more hands than I do.